Do RNA viruses require genome cyclisation for replication?
نویسندگان
چکیده
منابع مشابه
Rapid Genome Sequencing of RNA Viruses
We developed a system for rapid determination of viral RNA sequences whereby genomic sequence is obtained from cultured virus isolates without subcloning into plasmid vectors. This method affords new opportunities to address the challenges of unknown or untypeable emerging viruses.
متن کاملGenome packaging by spherical plant RNA viruses.
The majority of positive-strand RNA viruses of plants replicate and selectively encapsidate their progeny genomes into stable virions in cytoplasmic compartments of the cell where the opportunity to copackage cellular RNA also exists. Remarkably, highly purified infectious virions contain almost exclusively viral RNA, suggesting that mechanisms exist to regulate preferential packaging of viral ...
متن کاملdo scientometric indices require revision?
the scientific output of a researcher includes academic publications, creditability of these publications and number of citations. universities and institutions evaluating the research activities have always taken into account the academic status and ranking of the researchers. selection and application of an appropriate method to assess the academic activities have also been a concern for scie...
متن کاملDynamics of alternative modes of RNA replication for positive-sense RNA viruses.
We propose and study nonlinear mathematical models describing the intracellular time dynamics of viral RNA accumulation for positive-sense single-stranded RNA viruses. Our models consider different replication modes ranging between two extremes represented by the geometric replication (GR) and the linear stamping machine replication (SMR). We first analyse a model that quantitatively reproduced...
متن کاملStructural basis for RNA-genome recognition during bacteriophage Qβ replication
Upon infection of Escherichia coli by bacteriophage Qβ, the virus-encoded β-subunit recruits host translation elongation factors EF-Tu and EF-Ts and ribosomal protein S1 to form the Qβ replicase holoenzyme complex, which is responsible for amplifying the Qβ (+)-RNA genome. Here, we use X-ray crystallography, NMR spectroscopy, as well as sequence conservation, surface electrostatic potential and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2013
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2013.04.005